Heat Shock 70kDa Protein 8 (HSPA8)

LAP1; HSC54; HSC70; HSC71; HSP71; HSPA10; NIP71; HSP73; Heat shock cognate 71 kDa protein; Lipopolysaccharide-associated protein 1; LPS-associated protein 1

SPN	T721
HGNC	5241
MGI	105384
PubMed	24121476
RGD	621725
UniProt	P11142
Wiki	HSPA8

The product encoded by this gene belongs to the heat shock protein 70 (Hsp70) family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein known as Hsc70. This protein binds to nascent polypeptides to facilitate correct protein folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date.

HSPA8 is ATPase that works with auxilin to remove clathrin coated vesicles. In neurons, synaptojanin is also an important protein involved in vesicle uncoating.

Reference

"Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein."
Nucleic Acids Res. 15:5181-5197(1987) [PubMed] [Europe PMC] [Abstract]

"Molecular and functional characterization of HSC54, a novel variant of human heat shock cognate protein 70."
Mol. Pharmacol. 58:1257-1263(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]