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Carbonic Anhydrase VI (CA6)

CA-VI; CAVI; GUSTIN; Carbonate dehydratase VI; Salivary carbonic anhydrase; Secreted carbonic anhydrase

Carbonic anhydrase 6 is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown.The clones identified a 1.45-kb mRNA that was present in high levels in parotid submandibular salivary glands but absent in other tissues such as sublingual gland, kidney, liver, and prostate. The mature CA VI protein has 291 amino acids, compared to the 259 or 260 residues of the cytoplasmic isozymes; most of the extra amino acids present are in the carboxyl terminal region. The CA VI protein has 35% sequence identity with human CA II, while residues involved in the active site of the enzymes have been conserved. Southern analysis of human DNA indicated that there is only 1 gene coding for CA VI.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT713Hu01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT713Hu01 Monoclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
PAT713Hu01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IF.
Assay Kits CLT713Hu01 CLIA Kit for Carbonic Anhydrase VI (CA6) CLIA assay for Antigen Detection
ELT713Hu01 ELISA Kit for Carbonic Anhydrase VI (CA6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT713Mu01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT713Mu01 Monoclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
PAT713Mu01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IF.
Assay Kits CLT713Mu01 CLIA Kit for Carbonic Anhydrase VI (CA6) CLIA assay for Antigen Detection
ELT713Mu01 ELISA Kit for Carbonic Anhydrase VI (CA6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT713Ra01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT713Ra01 Monoclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
PAT713Ra01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IF.
Assay Kits CLT713Ra01 CLIA Kit for Carbonic Anhydrase VI (CA6) CLIA assay for Antigen Detection
ELT713Ra01 ELISA Kit for Carbonic Anhydrase VI (CA6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT713Ca01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT713Ca01 Monoclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
PAT713Ca01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IF.
Assay Kits CLT713Ca01 CLIA Kit for Carbonic Anhydrase VI (CA6) CLIA assay for Antigen Detection
ELT713Ca01 ELISA Kit for Carbonic Anhydrase VI (CA6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT713Po01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT713Po01 Monoclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
PAT713Po01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IF.
Assay Kits CLT713Po01 CLIA Kit for Carbonic Anhydrase VI (CA6) CLIA assay for Antigen Detection
ELT713Po01 ELISA Kit for Carbonic Anhydrase VI (CA6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT713Bo01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT713Bo01 Monoclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
PAT713Bo01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IF.
Assay Kits CLT713Bo01 CLIA Kit for Carbonic Anhydrase VI (CA6) CLIA assay for Antigen Detection
ELT713Bo01 ELISA Kit for Carbonic Anhydrase VI (CA6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT713Rb01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT713Rb01 Monoclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
PAT713Rb01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IF.
Assay Kits CLT713Rb01 CLIA Kit for Carbonic Anhydrase VI (CA6) CLIA assay for Antigen Detection
ELT713Rb01 ELISA Kit for Carbonic Anhydrase VI (CA6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT713Mo01 Recombinant Carbonic Anhydrase VI (CA6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT713Mo01 Monoclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IP.
PAT713Mo01 Polyclonal Antibody to Carbonic Anhydrase VI (CA6) WB; IHC; ICC; IF.
Assay Kits CLT713Mo01 CLIA Kit for Carbonic Anhydrase VI (CA6) CLIA assay for Antigen Detection
ELT713Mo01 ELISA Kit for Carbonic Anhydrase VI (CA6) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry."
Biochemistry 30:569-575(1991) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."
Angew. Chem. Int. Ed. Engl. 46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]

"Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."
Bioorg. Med. Chem. Lett. 17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]

"A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."
Bioorg. Med. Chem. Lett. 19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]

"Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."
J. Am. Chem. Soc. 131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human erythrocyte carbonic anhydrase C. VI. The three-dimensional structure at high resolution in relation to other mammalian carbonic anhydrases."
Cold Spring Harb. Symp. Quant. Biol. 36:221-231(1972) [PubMed] [Europe PMC] [Abstract]