Acid Phosphatase 6, Lysophosphatidic (ACP6)

LPAP; ACPL1; PACPL1; Acid phosphatase-like protein 1; Lysophosphatidic acid phosphatase type 6

SPN	T698
HGNC	29609
MGI	1931010
PubMed	16685394
RGD	1306336
UniProt	Q9NPH0
Wiki	ACP6

Lysophosphatidic acid phosphatase type 6 is an enzyme encoded by the ACP6 gene.Two initiation codons were identified, resulting in proteins of 428 and 421 amino acids, respectively, and the authors reported that the second ATG was the initiation codon in ACP6. The protein has a signal sequence and an N-terminal consensus sequence shared by a group of acid phosphatases, and it shares 28.5% amino acid identity with ACPP. Northern blot analysis detected a 1.75-kb transcript in all tissues examined with higher expression in kidney, heart, small intestine, muscle, and liver. They showed that ACP6 was localized to mitochondria by signal peptides and regulated the biosynthesis of mitochondrial lipids by hydrolyzing lysophosphatidic acid (LPA) to monoacylglycerol.

Reference

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"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6."
Protein Cell 4:548-561(2013) [PubMed] [Europe PMC] [Abstract]