Low Density Lipoprotein Receptor Related Protein 8 (LRP8)

APOER2; Apolipoprotein E Receptor 2

SPN	T687
HGNC	6700
MGI	1340044
PubMed	22589174
RGD	1305729
UniProt	Q14114
Wiki	LRP8

8is a member of the LDL receptor family that plays a role in endocytosis and signal transduction. Together with VLDLR it is able to bind reelin, leading to the phosphorylation of DAB1, which binds on its cytosolic tail.This gene encodes an apolipoprotein E receptor, a member of the low density lipoprotein receptor (LDLR) family. Apolipoprotein E is a small lipophilic plasma protein and a component of lipoproteins such as chylomicron remnants, very low density lipoprotein (VLDL), and high density lipoprotein (HDL). The apolipoprotein E receptor is involved in cellular recognition and internalization of these lipoproteins. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.ApoER2 also regulates selenium intake into cells through endocytosis of SEPP1.

Reference

"Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain."
J. Biol. Chem. 271:8373-8380(1996) [PubMed] [Europe PMC] [Abstract]

"Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene."
J. Biol. Chem. 272:8498-8504(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue."
J. Biol. Chem. 276:13192-13197(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression and alternate splicing of apolipoprotein E receptor 2 in brain."
Neuroscience 90:903-911(1999) [PubMed] [Europe PMC] [Abstract]

"Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells."
FEBS Lett. 540:181-187(2003) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of LRP8 (apoER2) in human blood platelets."
J. Lipid Res. 40:1925-1930(1999) [PubMed] [Europe PMC] [Abstract]

"Differential binding of ligands to the apolipoprotein E receptor 2."
Biochemistry 42:9355-9364(2003) [PubMed] [Europe PMC] [Abstract]

"Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain."
Biochemistry 42:10406-10417(2003) [PubMed] [Europe PMC] [Abstract]

"Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'."
J. Biol. Chem. 278:33831-33838(2003) [PubMed] [Europe PMC] [Abstract]

"The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2."
J. Biol. Chem. 283:2363-2372(2008) [PubMed] [Europe PMC] [Abstract]

"The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
J. Biol. Chem. 285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]

"Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease."
Neurosci. Lett. 332:216-218(2002) [PubMed] [Europe PMC] [Abstract]

"An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction."
Am. J. Hum. Genet. 81:780-791(2007) [PubMed] [Europe PMC] [Abstract]