Antigen Peptide Transporter 1 (TAP1)

APT1; ABC17; ABCB2; PSF1; RING4; Y3; TAP1N; Peptide Supply Factor 1; Atp-Binding Cassette,Subfamily B,Member 2; Peptide transporter involved in antigen processing 1

SPN	T674
HGNC	43
MGI	98483
PubMed	1473153
RGD	3817
UniProt	Q03518
Wiki	TAP1

member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.

Reference

"Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters."
Nature 348:741-744(1990) [PubMed] [Europe PMC] [Abstract]

"DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."
J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract]

"Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility."
Proc. Natl. Acad. Sci. U.S.A. 90:11079-11083(1993) [PubMed] [Europe PMC] [Abstract]

"A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway."
Nature 348:744-747(1990) [PubMed] [Europe PMC] [Abstract]

"New allelic polymorphisms in TAP genes."
Immunogenetics 39:374-374(1994) [PubMed] [Europe PMC] [Abstract]

"Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region."
Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract]

"A viral inhibitor of peptide transporters for antigen presentation."
Nature 375:415-418(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47."
EMBO J. 15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract]

"Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site."
J. Immunol. 157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract]

"Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10."
Blood 90:2390-2397(1997) [PubMed] [Europe PMC] [Abstract]

"The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP."
Immunity 6:613-621(1997) [PubMed] [Europe PMC] [Abstract]

"Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome."
J. Clin. Invest. 103:755-758(1999) [PubMed] [Europe PMC] [Abstract]

"Adenovirus E19 has two mechanisms for affecting class I MHC expression."
J. Immunol. 162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract]

"The human cytomegalovirus gene product US6 inhibits ATP binding by TAP."
EMBO J. 20:387-396(2001) [PubMed] [Europe PMC] [Abstract]

"Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."
Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract]

"Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation."
J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing."
EMBO J. 20:4964-4972(2001) [PubMed] [Europe PMC] [Abstract]

"Allelic variants of the human putative peptide transporter involved in antigen processing."
Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract]

"A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer."
Nat. Genet. 13:210-213(1996) [PubMed] [Europe PMC] [Abstract]

"TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies."
Hum. Immunol. 62:256-268(2001) [PubMed] [Europe PMC] [Abstract]

"Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases."
Hum. Immunol. 64:823-829(2003) [PubMed] [Europe PMC] [Abstract]