WAP Four Disulfide Core Domain Protein 2 (WFDC2)

WFDC2; HE4; WAP5; EDDM4; Epididymal Protein 4; Epididymal Secretory Protein E4; Putative Protease Inhibitor WAP5; Major epididymis-specific protein E4

SPN	T671
HGNC	15939
MGI	1914951
PubMed	12839961
RGD	628757
UniProt	Q14508
Wiki	WFDC2

WAP four-disulfide core domain protein 2 is a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.

Reference

"A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors."
Biol. Reprod. 45:350-357(1991) [PubMed] [Europe PMC] [Abstract]

"The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms."
Oncogene 21:2768-2773(2002) [PubMed] [Europe PMC] [Abstract]

"The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma."
Cancer Res. 63:3695-3700(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas."
Cancer Res. 65:2162-2169(2005) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

"Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor."
PLoS ONE 7:E47672-E47672(2012) [PubMed] [Europe PMC] [Abstract]