Cholinergic Receptor, Nicotinic, Alpha 5 (CHRNa5)

CHR-NA5; CHRN-A5; N-AChRA5; NAChRA5; N-AChR-A5; Neuronal Acetylcholine Receptor Alpha 5

SPN	T640
HGNC	1959
MGI	87889
PubMed	22868939
RGD	2347
UniProt	P30532
Wiki	CHRNA5

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. See MIM 118508 for additional background information on AChRs.

The predicted 468-amino acid protein has a putative 22-amino acid signal peptide. The mature protein is 87% identical to rat alpha-5 protein. On Northern blots, alpha-5 was expressed in almost all neuronal and nonneuronal cells tested as 2 major transcripts of 2.7 and 2.1 kb, with additional mRNAs seen in 1 neuroblastoma cell line.

Reference

"Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines."
Proc. Natl. Acad. Sci. U.S.A. 89:1572-1576(1992) [PubMed] [Europe PMC] [Abstract]

"Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Genomics: when the smoke clears."
Nature 452:537-538(2008) [PubMed] [Europe PMC] [Abstract]

"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25."
Nature 452:633-637(2008) [PubMed] [Europe PMC] [Abstract]

"Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1."
Nat. Genet. 40:616-622(2008) [PubMed] [Europe PMC] [Abstract]