Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)

CHR-NA3; CHRN-A3; N-AChRA3; NAChRA3; N-AChR-A3; Neuronal Acetylcholine Receptor Alpha 3

SPN	T639
HGNC	1957
MGI	87887
PubMed	20234319
RGD	2345
UniProt	P32297
Wiki	CHRNA3

Neuronal acetylcholine receptor subunit alpha-3 is a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues.

The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT639Hu01	Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT639Hu01	Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IP.
Antibodies	PAT639Hu01	Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IF.
Assay Kits	CLT639Hu01	CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	CLIA assay for Antigen Detection
Assay Kits	ELT639Hu01	ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT639Mu01	Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT639Mu01	Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IP.
Antibodies	PAT639Mu01	Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IF.
Assay Kits	CLT639Mu01	CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	CLIA assay for Antigen Detection
Assay Kits	ELT639Mu01	ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT639Ra01	Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT639Ra01	Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IP.
Antibodies	PAT639Ra01	Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IF.
Assay Kits	CLT639Ra01	CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	CLIA assay for Antigen Detection
Assay Kits	ELT639Ra01	ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT639Ca01	Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT639Ca01	Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IP.
Antibodies	PAT639Ca01	Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IF.
Assay Kits	CLT639Ca01	CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	CLIA assay for Antigen Detection
Assay Kits	ELT639Ca01	ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT639Po01	Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT639Po01	Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IP.
Antibodies	PAT639Po01	Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IF.
Assay Kits	CLT639Po01	CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	CLIA assay for Antigen Detection
Assay Kits	ELT639Po01	ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT639Bo01	Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT639Bo01	Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IP.
Antibodies	PAT639Bo01	Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IF.
Assay Kits	CLT639Bo01	CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	CLIA assay for Antigen Detection
Assay Kits	ELT639Bo01	ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT639Rb01	Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT639Rb01	Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IP.
Antibodies	PAT639Rb01	Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IF.
Assay Kits	CLT639Rb01	CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	CLIA assay for Antigen Detection
Assay Kits	ELT639Rb01	ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT639Mo01	Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT639Mo01	Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IP.
Antibodies	PAT639Mo01	Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	WB; IHC; ICC; IF.
Assay Kits	CLT639Mo01	CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	CLIA assay for Antigen Detection
Assay Kits	ELT639Mo01	ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of human neuronal nicotinic receptor alpha 3-subunit."
Neurosci. Lett. 111:351-356(1990) [PubMed] [Europe PMC] [Abstract]

"Expression of mRNAs in human thymus coding for the alpha 3 subunit of a neuronal acetylcholine receptor."
Exp. Neurol. 111:175-180(1991) [PubMed] [Europe PMC] [Abstract]

"Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]

"The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."
Hum. Genet. 103:645-653(1998) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4."
J. Hum. Genet. 46:362-366(2001) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]

"Genomics: when the smoke clears."
Nature 452:537-538(2008) [PubMed] [Europe PMC] [Abstract]

"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25."
Nature 452:633-637(2008) [PubMed] [Europe PMC] [Abstract]

"A variant associated with nicotine dependence, lung cancer and peripheral arterial disease."
Nature 452:638-642(2008) [PubMed] [Europe PMC] [Abstract]

"Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1."
Nat. Genet. 40:616-622(2008) [PubMed] [Europe PMC] [Abstract]