5'-3'Exoribonuclease 1 (XRN1)

SEP1; Exoribonuclease I; Strand-exchange protein 1 homolog

SPN	T615
HGNC	30654
MGI	891964
PubMed	10790382
RGD	1309713
UniProt	Q8IZH2
Wiki	XRN1

XRN1 is an exoribonuclease enzyme. This enzyme is involves in 5’ to 3’ RNA degradation.The deduced 1,694-amino acid protein has a calculated molecular mass of 190 kD. It shares 92% homology with mouse Sep1, which the authors called Dhm1, over the N-terminal and central portions of the molecule, but only 74% homology at the C terminus. Northern blot analysis detected a predominant 10-kb transcript in all cells and organs tested except lung, liver, and kidney. Minor bands of about 5.5 kb were detected in testis and placenta. Epitope-tagged SEP1 was recovered in the cytoplasmic fraction of transfected 293 cells and showed an apparent molecular mass of about 208 kD. Fluorescence-tagged SEP1 localized to the cytoplasm, particularly the nuclear periphery, of transfected HeLa cells.

Reference

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