Paraoxonase 2 (PON2)

Serum Paraoxonase/Arylesterase 2; Paraoxonase Nirs; Aromatic esterase 2; Serum aryldialkylphosphatase 2

SPN	T605
HGNC	9205
MGI	106687
PubMed	21836061
RGD	1309954
UniProt	Q15165
Wiki	PON2

Serum paraoxonase/arylesterase 2 is a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress.

Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Reference

"The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family."
Genomics 33:498-507(1996) [PubMed] [Europe PMC] [Abstract]

"Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence."
Gene 213:149-157(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein."
J. Biol. Chem. 276:44444-44449(2001) [PubMed] [Europe PMC] [Abstract]

"Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities."
J. Lipid Res. 46:1239-1247(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus."
J. Clin. Endocrinol. Metab. 82:3373-3377(1997) [PubMed] [Europe PMC] [Abstract]

"DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease."
Am. J. Hum. Genet. 62:36-44(1998) [PubMed] [Europe PMC] [Abstract]