Nucleobindin 1 (NUCB1)

NUC; CALNUC

SPN	T603
HGNC	8043
MGI	97388
PubMed	10446275
RGD	620030
UniProt	Q02818
Wiki	NUCB1

Nucleobindin (Nuc) was first identified as a secreted protein of 55 kD that promotes production of DNA-specific antibodies in lupus-prone mice with the lymphoproliferation (lpr) mutation (Kanai et al., 1993). These mice produce large amounts of antibody against both single-stranded and double-stranded DNA (Theofilopoulos and Dixon, 1985). The primary defect is a deficiency in expression of the Fas gene. Analysis of cDNA that encodes mouse Nuc demonstrated that the protein is composed of a signal peptide, a DNA-binding site, 2 calcium-binding motifs, and a leucine zipper (Miura et al., 1992).

Miura et al. (1996) cloned human NUC, which encodes a deduced 461-amino acid peptide. A 2.4-kb NUC transcript was expressed in all organs examined.

Reference

"Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure."
Biochem. Biophys. Res. Commun. 187:375-380(1992) [PubMed] [Europe PMC] [Abstract]

"Organization of the human gene for nucleobindin (NUC) and its chromosomal assignment to 19q13.2-q13.4."
Genomics 34:181-186(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Interaction of the protein nucleobindin with G alpha i2, as revealed by the yeast two-hybrid system."
FEBS Lett. 373:155-158(1995) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Resveratrol-induced changes of the human adipocyte secretion profile."
J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]

"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structural studies on the Ca2+-binding domain of human nucleobindin (Calnuc)."
Biochemistry 43:10039-10049(2004) [PubMed] [Europe PMC] [Abstract]