Glucosidase Alpha, Neutral AB (GaNAB)

GluII; G2AN; Alpha-glucosidase 2; Glucosidase II subunit alpha

SPN	T594
HGNC	4138
MGI	1097667
PubMed	21642380
RGD	1309775
UniProt	Q14697
Wiki	GANAB

Human tissues contain 2 isozymes of neutral alpha-glucosidase designated AB (GANAB) and C (GANC). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, the two have been shown to have other differences including those of substrate specificity. Since the AB form of mouse is not different electrophoretically from that in man, Martiniuk et al. used rocket immunoelectrophoresis to distinguish the enzymes from the 2 species.

Trombetta et al. (1996) isolated enzymatically active glucosidase II from rat liver and found that it was composed of 2 subunits, alpha and beta. Based on peptide sequences of the purified enzyme, they identified the corresponding human cDNAs in existing sequence databases.

Reference

"The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo."
Glycobiology 10:815-827(2000) [PubMed] [Europe PMC] [Abstract]

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, Submitted (MAR-2007) to UniProtKB

"Identity of neutral alpha-glucosidase AB and the glycoprotein processing enzyme glucosidase II. Biochemical and genetic studies."
J. Biol. Chem. 260:1238-1242(1985) [PubMed] [Europe PMC] [Abstract]

"Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit."
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