Chorionic Gonadotropin Beta Polypeptide (CGb)

CG-B; CGB3; hCGB; HCG; CGb5; CGb7; CGb8; Choriogonadotropin subunit beta

SPN	T566
HGNC	1886
PubMed	2455489
UniProt	P01233
Wiki	CGB

By restriction digest analysis, Talmadge et al. (1983) determined that the 7 CGB genes are extremely similar but not identical. Otani et al. (1988) found that CGB3 and CBG8 were expressed at 2-fold lower levels than CGB5 following transfection into a mouse adrenocortical cell line.

Bo and Boime (1992) determined that most of the sequence variation among the CGB genes occurs in the nontranslated region of exon 1. They further found that CGB3 was expressed at about the same levels at CGB8 in first trimester placenta and in a choriocarcinoma cell line, and both were expressed at a lower level than CGB5. Jameson and Lindell (1988) determined that each of the CGB genes contains 3 exons. Otani et al. (1988) determined that the promoter regions contain no CAAT or TATAA boxes.

Reference

"The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region."
Nature 286:684-687(1980) [PubMed] [Europe PMC] [Abstract]

"Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone."
Nature 307:37-40(1984) [PubMed] [Europe PMC] [Abstract]

"The beta subunit of human chorionic gonadotropin is encoded by multiple genes."
J. Biol. Chem. 258:11492-11499(1983) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin."
J. Biol. Chem. 256:1816-1823(1981) [PubMed] [Europe PMC] [Abstract]

"A map of the hCG beta-LH beta gene cluster."
J. Biol. Chem. 261:5907-5916(1986) [PubMed] [Europe PMC] [Abstract]

"Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection."
Mol. Biol. Evol. 19:320-335(2002) [PubMed] [Europe PMC] [Abstract]

"The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit."
J. Biol. Chem. 250:5247-5258(1975) [PubMed] [Europe PMC] [Abstract]

"Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit."
J. Biol. Chem. 248:6810-6827(1973) [PubMed] [Europe PMC] [Abstract]

"Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin."
J. Biol. Chem. 256:6587-6592(1981) [PubMed] [Europe PMC] [Abstract]

"Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form."
J. Biol. Chem. 265:312-317(1990) [PubMed] [Europe PMC] [Abstract]

"Site-specific N-glycosylation of human chorionic gonadotrophin --structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy."
Glycobiology 1:393-404(1991) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human chorionic gonadotropin."
Nature 369:455-461(1994) [PubMed] [Europe PMC] [Abstract]