Prothymosin Alpha (PTMa)

TMSA; PTM-A; Pro-Thymosin A; Gene Sequence 28; Thymosin alpha-1

SPN	T560
HGNC	9623
MGI	97803
PubMed	15657435
RGD	61829
UniProt	P06454
Wiki	PTMA

Prothymosin alpha is a protein encoded by the PTMA. PTMA is a small, 12.4 kDa protein. It is a 109-111 amino acid long polypeptide as the precursor of thymosin alpha-1. The encoded human PTMA protein is a highly acidic (54 residues out of 111) and shared over 90% sequence homology with rat PTMA. The primary structure of PTMA is highly conserved and shows a number of important features. The first 28 amino acids of its sequence correspond to those of thymosin-alpha-1. It has a central acidic region (residues 41-85) comprising of glutamic and aspartic residues. Neither type of secondary structure has been detected. Thymosin-alpha-1 appeared at positions 2-29 of the PTMA.PTMA has been shown to serve essential biological functions.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT560Hu01	Recombinant Prothymosin Alpha (PTMa)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT560Hu01	Monoclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IP.
Antibodies	PAT560Hu01	Polyclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IF.
Assay Kits	CLT560Hu01	CLIA Kit for Prothymosin Alpha (PTMa)	CLIA assay for Antigen Detection
Assay Kits	ELT560Hu01	ELISA Kit for Prothymosin Alpha (PTMa)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT560Mu01	Recombinant Prothymosin Alpha (PTMa)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT560Mu01	Monoclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IP.
Antibodies	PAT560Mu01	Polyclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IF.
Assay Kits	CLT560Mu01	CLIA Kit for Prothymosin Alpha (PTMa)	CLIA assay for Antigen Detection
Assay Kits	ELT560Mu01	ELISA Kit for Prothymosin Alpha (PTMa)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT560Ra01	Recombinant Prothymosin Alpha (PTMa)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT560Ra01	Monoclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IP.
Antibodies	PAT560Ra01	Polyclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IF.
Assay Kits	CLT560Ra01	CLIA Kit for Prothymosin Alpha (PTMa)	CLIA assay for Antigen Detection
Assay Kits	ELT560Ra01	ELISA Kit for Prothymosin Alpha (PTMa)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT560Ca01	Recombinant Prothymosin Alpha (PTMa)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT560Ca01	Monoclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IP.
Antibodies	PAT560Ca01	Polyclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IF.
Assay Kits	CLT560Ca01	CLIA Kit for Prothymosin Alpha (PTMa)	CLIA assay for Antigen Detection
Assay Kits	ELT560Ca01	ELISA Kit for Prothymosin Alpha (PTMa)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT560Po01	Recombinant Prothymosin Alpha (PTMa)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT560Po01	Monoclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IP.
Antibodies	PAT560Po01	Polyclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IF.
Assay Kits	CLT560Po01	CLIA Kit for Prothymosin Alpha (PTMa)	CLIA assay for Antigen Detection
Assay Kits	ELT560Po01	ELISA Kit for Prothymosin Alpha (PTMa)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT560Bo01	Recombinant Prothymosin Alpha (PTMa)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT560Bo01	Monoclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IP.
Antibodies	PAT560Bo01	Polyclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IF.
Assay Kits	CLT560Bo01	CLIA Kit for Prothymosin Alpha (PTMa)	CLIA assay for Antigen Detection
Assay Kits	ELT560Bo01	ELISA Kit for Prothymosin Alpha (PTMa)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT560Rb01	Recombinant Prothymosin Alpha (PTMa)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT560Rb01	Monoclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IP.
Antibodies	PAT560Rb01	Polyclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IF.
Assay Kits	CLT560Rb01	CLIA Kit for Prothymosin Alpha (PTMa)	CLIA assay for Antigen Detection
Assay Kits	ELT560Rb01	ELISA Kit for Prothymosin Alpha (PTMa)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT560Mo01	Recombinant Prothymosin Alpha (PTMa)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT560Mo01	Monoclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IP.
Antibodies	PAT560Mo01	Polyclonal Antibody to Prothymosin Alpha (PTMa)	WB; IHC; ICC; IF.
Assay Kits	CLT560Mo01	CLIA Kit for Prothymosin Alpha (PTMa)	CLIA assay for Antigen Detection
Assay Kits	ELT560Mo01	ELISA Kit for Prothymosin Alpha (PTMa)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Molecular cloning of cDNA for human prothymosin alpha."
Proc. Natl. Acad. Sci. U.S.A. 83:8926-8928(1986) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

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"Human prothymosin alpha: amino acid sequence and immunologic properties."
Arch. Biochem. Biophys. 250:197-201(1986) [PubMed] [Europe PMC] [Abstract]

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Biochemistry 32:4587-4596(1993) [PubMed] [Europe PMC] [Abstract]

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Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

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Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

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"Initial characterization of the human central proteome."
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"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
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"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"NMR structure of human thymosin alpha-1."
Biochem. Biophys. Res. Commun. 416:356-361(2011) [PubMed] [Europe PMC] [Abstract]