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Keratin 6A (KRT6A)

K6A; KRT6C; KRT6D; CK6C; K6C; CK6D; K6D; Keratin 6C; Keratin 6D; Keratin, type II cytoskeletal 6A; Type-II keratin Kb6

Keratin 6A is a type II cytokeratin, one of a number of isoforms of keratin 6 encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. It is found with keratin 16 and/or keratin 17 in the palm and sole epidermis, the epithelial cells of the nail bed, the filiform papillae of the tongue, the epithelial lining of oral mucosa and esophagus, as well as the hair follicles. This keratin 6 isoform is thought to be the most abundant of the K6 isoforms.
The KRT6A gene consists of 9 exons separated by 8 introns and is located in the type II keratin gene cluster on human chromosome 12q. Keratin 6B and keratin 6C are encoded by the neighbouring genes, which are identical in intron-exon organization to KRT6A and are more than 99% identical in their DNA coding sequences.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins T547Hu01 Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies MT547Hu21 Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
PT547Hu01 Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
LT547Hu71 Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits KET547Hu ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins T547Ra01 Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
PT547Ra01 Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Keratin 6A (KRT6A) Bioactivity
Antibodies NONE Monoclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Keratin 6A (KRT6A) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Keratin 6A (KRT6A) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Keratin 6A (KRT6A) CLIA assay for Antigen Detection

Reference

"Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms."
J. Biol. Chem. 270:18581-18592(1995) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAR-2008) to UniProtKB

"The cDNA sequence of a type II cytoskeletal keratin reveals constant and variable structural domains among keratins."
Cell 33:915-924(1983) [PubMed] [Europe PMC] [Abstract]

"Identification of trichoplein, a novel keratin filament-binding protein."
J. Cell Sci. 118:1081-1090(2005) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita pedigrees with fissured tongue or diffuse plantar keratoderma."
Eur. J. Dermatol. 22:476-480(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Mutation of a type II keratin gene (K6a) in pachyonychia congenita."
Nat. Genet. 10:363-365(1995) [PubMed] [Europe PMC] [Abstract]

"A mutation detection strategy for the human keratin 6A gene and novel missense mutations in two cases of pachyonychia congenita type 1."
Exp. Dermatol. 8:109-114(1999) [PubMed] [Europe PMC] [Abstract]

"Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita."
J. Invest. Dermatol. 117:1391-1396(2001) [PubMed] [Europe PMC] [Abstract]

"[A de nono I462S mutation in the KRT6A gene is associated with pachyonychia congenita type I]."
Zhonghua Yi Xue Za Zhi 84:1344-1347(2004) [PubMed] [Europe PMC] [Abstract]

"A severe case of pachyonychia congenita type I due to a novel proline mutation in keratin 6a."
Br. J. Dermatol. 152:800-802(2005) [PubMed] [Europe PMC] [Abstract]

"The genetic basis of pachyonychia congenita."
J. Investig. Dermatol. Symp. Proc. 10:21-30(2005) [PubMed] [Europe PMC] [Abstract]

"A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita."
J. Dermatol. Sci. 48:199-205(2007) [PubMed] [Europe PMC] [Abstract]

"A novel missense mutation L468Q of keratin 6a in pachyonychia congenita type 1."
J. Eur. Acad. Dermatol. Venereol. 21:351-355(2007) [PubMed] [Europe PMC] [Abstract]

"Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1: report of a novel and a recently reported mutation in two unrelated Chinese families."
Br. J. Dermatol. 159:238-240(2008) [PubMed] [Europe PMC] [Abstract]

"Novel and recurrent keratin 6A (KRT6A) mutations in Chinese patients with pachyonychia congenita type 1."
Br. J. Dermatol. 160:1327-1329(2009) [PubMed] [Europe PMC] [Abstract]

"A large mutational study in pachyonychia congenita."
J. Invest. Dermatol. 131:1018-1024(2011) [PubMed] [Europe PMC] [Abstract]