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Cyclin Dependent Kinase 8 (CDK8)

K35; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8

Cell division protein kinase 8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies MT538Hu21 Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
PT538Hu01 Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits KET538Hu ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
PT538Mu01 Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits KET538Mu ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Cyclin Dependent Kinase 8 (CDK8) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Cyclin Dependent Kinase 8 (CDK8) Bioactivity
Antibodies NONE Monoclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Cyclin Dependent Kinase 8 (CDK8) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Cyclin Dependent Kinase 8 (CDK8) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Cyclin Dependent Kinase 8 (CDK8) CLIA assay for Antigen Detection

Reference

"Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C."
Proc. Natl. Acad. Sci. U.S.A. 92:8871-8875(1995) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription."
Mol. Cell 2:213-222(1998) [PubMed] [Europe PMC] [Abstract]

"A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."
Mol. Cell 3:97-108(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Mol. Cell 3:541-541(1999)

"TFIIH is negatively regulated by cdk8-containing mediator complexes."
Nature 407:102-106(2000) [PubMed] [Europe PMC] [Abstract]

"Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover."
Mol. Cell 16:509-520(2004) [PubMed] [Europe PMC] [Abstract]

"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]

"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]

"Mediator modulates Gli3-dependent Sonic hedgehog signaling."
Mol. Cell. Biol. 26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder."
J. Mol. Biol. 412:251-266(2011) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]