Cyclin A1 (CCNA1)

CCN-A1

SPN	T518
HGNC	1577
MGI	108042
PubMed	9843212
RGD	1310639
UniProt	P78396
Wiki	Cyclin_A1

Cyclin-A1 is a protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event.

The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle.

Reference

"Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines."
Cancer Res. 57:913-920(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins."
Mol. Cell. Biol. 19:2400-2407(1999) [PubMed] [Europe PMC] [Abstract]

"Identification of interaction partners and substrates of the cyclin A1-CDK2 complex."
J. Biol. Chem. 279:33727-33741(2004) [PubMed] [Europe PMC] [Abstract]

"Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry."
Mol. Cell 42:511-523(2011) [PubMed] [Europe PMC] [Abstract]