Cyclin B2 (CCNB2)

CCN-B2; G2/mitotic-specific cyclin-B2

SPN	T516
HGNC	1580
MGI	88311
PubMed	21161946
RGD	1308176
UniProt	O95067
Wiki	Cyclin_B2

Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle until mitosis, where they fall abruptly due to degradation.

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT516Hu01	Recombinant Cyclin B2 (CCNB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT516Hu01	Monoclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IP.
Antibodies	PAT516Hu01	Polyclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IF.
Assay Kits	CLT516Hu01	CLIA Kit for Cyclin B2 (CCNB2)	CLIA assay for Antigen Detection
Assay Kits	ELT516Hu01	ELISA Kit for Cyclin B2 (CCNB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT516Mu01	Recombinant Cyclin B2 (CCNB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT516Mu01	Monoclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IP.
Antibodies	PAT516Mu01	Polyclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IF.
Assay Kits	CLT516Mu01	CLIA Kit for Cyclin B2 (CCNB2)	CLIA assay for Antigen Detection
Assay Kits	ELT516Mu01	ELISA Kit for Cyclin B2 (CCNB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT516Ra01	Recombinant Cyclin B2 (CCNB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT516Ra01	Monoclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IP.
Antibodies	PAT516Ra01	Polyclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IF.
Assay Kits	CLT516Ra01	CLIA Kit for Cyclin B2 (CCNB2)	CLIA assay for Antigen Detection
Assay Kits	ELT516Ra01	ELISA Kit for Cyclin B2 (CCNB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT516Ca01	Recombinant Cyclin B2 (CCNB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT516Ca01	Monoclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IP.
Antibodies	PAT516Ca01	Polyclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IF.
Assay Kits	CLT516Ca01	CLIA Kit for Cyclin B2 (CCNB2)	CLIA assay for Antigen Detection
Assay Kits	ELT516Ca01	ELISA Kit for Cyclin B2 (CCNB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT516Po01	Recombinant Cyclin B2 (CCNB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT516Po01	Monoclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IP.
Antibodies	PAT516Po01	Polyclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IF.
Assay Kits	CLT516Po01	CLIA Kit for Cyclin B2 (CCNB2)	CLIA assay for Antigen Detection
Assay Kits	ELT516Po01	ELISA Kit for Cyclin B2 (CCNB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT516Bo01	Recombinant Cyclin B2 (CCNB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT516Bo01	Monoclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IP.
Antibodies	PAT516Bo01	Polyclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IF.
Assay Kits	CLT516Bo01	CLIA Kit for Cyclin B2 (CCNB2)	CLIA assay for Antigen Detection
Assay Kits	ELT516Bo01	ELISA Kit for Cyclin B2 (CCNB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT516Rb01	Recombinant Cyclin B2 (CCNB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT516Rb01	Monoclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IP.
Antibodies	PAT516Rb01	Polyclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IF.
Assay Kits	CLT516Rb01	CLIA Kit for Cyclin B2 (CCNB2)	CLIA assay for Antigen Detection
Assay Kits	ELT516Rb01	ELISA Kit for Cyclin B2 (CCNB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT516Mo01	Recombinant Cyclin B2 (CCNB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT516Mo01	Monoclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IP.
Antibodies	PAT516Mo01	Polyclonal Antibody to Cyclin B2 (CCNB2)	WB; IHC; ICC; IF.
Assay Kits	CLT516Mo01	CLIA Kit for Cyclin B2 (CCNB2)	CLIA assay for Antigen Detection
Assay Kits	ELT516Mo01	ELISA Kit for Cyclin B2 (CCNB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]