Cytochrome P450 2C18 (CYP2C18)

CYP2C; CPCI; CYP2C17; CPCJ; P450C2C; limonene 6-monooxygenase; Mephenytoin 4-hydroxylase; Cytochrome P450 Family 2 Subfamily C Polypeptide 18

SPN	T480
HGNC	2620
PubMed	15301741
RGD	2469
UniProt	P33260
Wiki	CYP2C18

Cytochrome P450 2C18 isa member of the cytochrome P450 superfamily of enzymes. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19.

Cytochrome P450 2C19, a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.It is involved in the metabolism of several important groups of drugs including many proton pump inhibitors and antiepileptics.

Reference

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Biochemistry 30:3247-3255(1991) [PubMed] [Europe PMC] [Abstract]

Erratum
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Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

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"Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes."
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"Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese."
Mol. Pharmacol. 46:594-598(1994) [PubMed] [Europe PMC] [Abstract]

"Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele."
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"Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin."
J. Pharmacol. Exp. Ther. 286:1490-1495(1998) [PubMed] [Europe PMC] [Abstract]

"An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians."
Pharmacogenetics 8:129-135(1998) [PubMed] [Europe PMC] [Abstract]

"A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin."
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"A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation."
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"Genetic variations and haplotypes of CYP2C19 in a Japanese population."
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