Aldolase B, Fructose Bisphosphate (ALDOB)

ALDO-BL; Liver-type aldolase

SPN	T462
HGNC	417
MGI	87995
PubMed	15880727
RGD	2090
UniProt	P05062
Wiki	ALDOB

Aldolase B is an isoenzyme of fructose 1,6-bisphosphate aldolase (aldolase A), which is also capable of cleaving fructose 1-phosphate to form glyceraldehyde and dihydroxyacetone phosphate (DHAP). The reaction is reversible. Also known as Aldolase (Class I), it is found in the liver and kidney.

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13 ) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Defects of aldolase B cause fructose 1-phosphate to accumulate in tissues which contain fructokinase, a condition known as hereditary fructose intolerance.

Reference

"Isolation and nucleotide sequence of a full-length cDNA coding for aldolase B from human liver."
Nucleic Acids Res. 12:7401-7410(1984) [PubMed] [Europe PMC] [Abstract]

"Human aldolase isozyme gene: the structure of multispecies aldolase B mRNAs."
Nucleic Acids Res. 13:5055-5069(1985) [PubMed] [Europe PMC] [Abstract]

"Complete amino acid sequence for human aldolase B derived from cDNA and genomic clones."
Proc. Natl. Acad. Sci. U.S.A. 81:2738-2742(1984) [PubMed] [Europe PMC] [Abstract]

"Human aldolase B gene: characterization of the genomic aldolase B gene and analysis of sequences required for multiple polyadenylations."
J. Biochem. 102:1043-1051(1987) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human aldolase B gene."
Mol. Biol. Med. 3:245-264(1986) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"Construction and expression of human aldolase A and B expression plasmids in Escherichia coli host."
Biochim. Biophys. Acta 1007:334-342(1989) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of a cDNA clone for human aldolase B."
Biochem. Biophys. Res. Commun. 117:601-609(1983) [PubMed] [Europe PMC] [Abstract]

"Novel interaction partners of Bardet-Biedl syndrome proteins."
Cell Motil. Cytoskeleton 65:143-155(2008) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The structure of human liver fructose-1,6-bisphosphate aldolase."
Acta Crystallogr. D 57:1526-1533(2001) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene."
Hum. Mutat. 6:210-218(1995) [PubMed] [Europe PMC] [Abstract]

"Catalytic deficiency of human aldolase B in hereditary fructose intolerance caused by a common missense mutation."
Cell 53:881-885(1988) [PubMed] [Europe PMC] [Abstract]

"Molecular analysis of aldolase B genes in hereditary fructose intolerance."
Lancet 335:306-309(1990) [PubMed] [Europe PMC] [Abstract]

"A partially active mutant aldolase B from a patient with hereditary fructose intolerance."
FASEB J. 8:107-113(1994) [PubMed] [Europe PMC] [Abstract]

"Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance."
Am. J. Hum. Genet. 56:1002-1005(1995) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel mutation (Leu 256-->Pro) in the human aldolase B gene associated with hereditary fructose intolerance."
Hum. Mol. Genet. 3:203-204(1994) [PubMed] [Europe PMC] [Abstract]

"A new aldolase B variant, N334K, is a common cause of hereditary fructose intolerance in Yugoslavia."
Nucleic Acids Res. 18:1925-1925(1990) [PubMed] [Europe PMC] [Abstract]

"Screening for hereditary fructose intolerance mutations by reverse dot-blot."
Mol. Cell. Probes 13:35-40(1999) [PubMed] [Europe PMC] [Abstract]

"Functional and molecular modelling studies of two hereditary fructose intolerance-causing mutations at arginine 303 in human liver aldolase."
Biochem. J. 350:823-828(2000) [PubMed] [Europe PMC] [Abstract]

"Molecular analysis of the aldolase B gene in patients with hereditary fructose intolerance from Spain."
J. Med. Genet. 39:E56-E56(2002) [PubMed] [Europe PMC] [Abstract]

"Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene."
Hum. Mutat. 24:534-534(2004) [PubMed] [Europe PMC] [Abstract]

"The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe."
Hum. Mutat. 25:594-594(2005) [PubMed] [Europe PMC] [Abstract]