Aldolase C, Fructose Bisphosphate (ALDOC)

ALDO-C; ALDC; ALD-C; Fructose-bisphosphate aldolase C; Brain-type aldolase

SPN	T461
HGNC	418
MGI	101863
PubMed	24475166
RGD	2091
UniProt	P09972
Wiki	ALDOC

Aldolase C, fructose-bisphosphate is a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose 1,6-bisphosphate and fructose-1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde 3-phosphate or glyceraldehyde, respectively.Rottmann et al. determined that the gene structure of ALDOC is the same as that in other aldolase genes in birds and mammals, having 9 exons separated by 8 introns, all in precisely the same positions, with only the intron sizes being different. One of the exons is noncoding. The entire gene is approximately 4 kb long. Buono et al. presented the complete nucleotide sequence of ALDOC.

Reference

"The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones."
Biochimie 69:137-145(1987) [PubMed] [Europe PMC] [Abstract]

"The complete nucleotide sequence of the gene coding for the human aldolase C."
Nucleic Acids Res. 16:4733-4733(1988) [PubMed] [Europe PMC] [Abstract]

"Characterization of the transcription-initiation site and of the promoter region within the 5' flanking region of the human aldolase C gene."
Eur. J. Biochem. 192:805-811(1990) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump."
J. Biol. Chem. 276:30407-30413(2001) [PubMed] [Europe PMC] [Abstract]

"Phospholipase D2 directly interacts with aldolase via its PH domain."
Biochemistry 41:3414-3421(2002) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function."
Protein Sci. 13:3077-3084(2004) [PubMed] [Europe PMC] [Abstract]