Proteasome 26S Subunit, ATPase 1 (PSMC1)

P26S4; S4; p56; 26S proteasome AAA-ATPase subunit RPT2; 26S protease regulatory subunit 4

SPN	T454
HGNC	9547
MGI	106054
PubMed	22948515
RGD	621097
UniProt	P62191
Wiki	PSMC1

Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMC1 encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.

Reference

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