Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b)

CAM2; CAMK2; CAMKB; Proline Rich Calmodulin-Dependent Protein Kinase

SPN	T449
HGNC	1461
MGI	88257
PubMed	21871176
RGD	2262
UniProt	Q13554
Wiki	CAMK2B

Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta.

The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene.

Reference

"Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities."
FEBS Lett. 475:107-110(2000) [PubMed] [Europe PMC] [Abstract]

"Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells."
Diabetologia 43:465-473(2000) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of novel human tumor cell-specific CaMK-II variants."
Biochim. Biophys. Acta 1355:281-292(1997) [PubMed] [Europe PMC] [Abstract]

"Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II."
J. Biol. Chem. 279:12484-12494(2004) [PubMed] [Europe PMC] [Abstract]

"SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation."
Neuron 43:563-574(2004) [PubMed] [Europe PMC] [Abstract]

"Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise."
J. Physiol. (Lond.) 574:889-903(2006) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Analysis of CaM-kinase signaling in cells."
Cell Calcium 50:1-8(2011) [PubMed] [Europe PMC] [Abstract]

"The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis."
Proc. Nutrit. Soc. 63:279-286(2004) [PubMed] [Europe PMC] [Abstract]

"The Ca2+-calmodulin dependent protein kinase II system of skeletal muscle sarcoplasmic reticulum."
Basic Appl. Myol. 15:5-17(2005)

"Calmodulin-kinases: modulators of neuronal development and plasticity."
Neuron 59:914-931(2008) [PubMed] [Europe PMC] [Abstract]

"The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag?"
Physiology (Bethesda) 24:357-366(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human calcium/calmodulin-dependent protein kinase IIb isoform 1 (CAMK2B)."
Submitted (DEC-2007) to the PDB data bank

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]