Interleukin 17 Receptor E (IL17RE)

IL17R-E

SPN	T433
HGNC	18439
MGI	1889371
PubMed	21993849
RGD	735148
UniProt	Q8NFR9

Interleukin 17 Receptor E is a protein that shares limited similarity with the interleukin-17 receptor. The function of the encoded protein has not yet been determined. Three alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

Functional IL-17R is a heteromeric complex consisting of at least IL17RA and IL17RC. A number of additional variants exist including IL17RB, which binds preferentially IL17B and IL17E.Receptor which can activate the MAPK signaling pathway and seems to function at or upstream of Ras By similarity. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

Reference

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway."
Cell. Signal. 18:1287-1298(2006) [PubMed] [Europe PMC] [Abstract]

"IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]

"IL-17C regulates the innate immune function of epithelial cells in an autocrine manner."
Nat. Immunol. 12:1159-1166(2011) [PubMed] [Europe PMC] [Abstract]