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Interleukin 17 Receptor D (IL17RD)

SEF; IL17RLM; IL-17RD; IL17R-D; IL17Rhom; Interleukin-17 receptor-like protein

Fibroblast growth factors (FGFs) are secreted proteins involved in cellular proliferation, migration, differentiation, and survival. FGF activity is negatively regulated by members of the 'sprouty' family . The SEF protein is a modulator of FGF signaling. The genomic coordinates used for the transcript record were based on transcript alignments.
Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituarity, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT432Hu01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT432Hu01 Monoclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
PAT432Hu01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IF.
Assay Kits CLT432Hu01 CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA assay for Antigen Detection
ELT432Hu01 ELISA Kit for Interleukin 17 Receptor D (IL17RD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT432Mu01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT432Mu01 Monoclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
PAT432Mu01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IF.
Assay Kits CLT432Mu01 CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA assay for Antigen Detection
ELT432Mu01 ELISA Kit for Interleukin 17 Receptor D (IL17RD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT432Ra01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT432Ra01 Monoclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
PAT432Ra01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IF.
Assay Kits CLT432Ra01 CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA assay for Antigen Detection
ELT432Ra01 ELISA Kit for Interleukin 17 Receptor D (IL17RD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT432Ca01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT432Ca01 Monoclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
PAT432Ca01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IF.
Assay Kits CLT432Ca01 CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA assay for Antigen Detection
ELT432Ca01 ELISA Kit for Interleukin 17 Receptor D (IL17RD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT432Po01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT432Po01 Monoclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
PAT432Po01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IF.
Assay Kits CLT432Po01 CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA assay for Antigen Detection
ELT432Po01 ELISA Kit for Interleukin 17 Receptor D (IL17RD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT432Bo01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT432Bo01 Monoclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
PAT432Bo01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IF.
Assay Kits CLT432Bo01 CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA assay for Antigen Detection
ELT432Bo01 ELISA Kit for Interleukin 17 Receptor D (IL17RD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT432Rb01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT432Rb01 Monoclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
PAT432Rb01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IF.
Assay Kits CLT432Rb01 CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA assay for Antigen Detection
ELT432Rb01 ELISA Kit for Interleukin 17 Receptor D (IL17RD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT432Mo01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT432Mo01 Monoclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
PAT432Mo01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IF.
Assay Kits CLT432Mo01 CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA assay for Antigen Detection
ELT432Mo01 ELISA Kit for Interleukin 17 Receptor D (IL17RD) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling."
J. Biol. Chem. 278:50273-50282(2003) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity."
Proc. Natl. Acad. Sci. U.S.A. 101:1229-1234(2004) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling."
J. Biol. Chem. 278:33232-33238(2003) [PubMed] [Europe PMC] [Abstract]

"Sef is a spatial regulator for Ras/MAP kinase signaling."
Dev. Cell 7:33-44(2004) [PubMed] [Europe PMC] [Abstract]

"Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism."
Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]