Interleukin 17 Receptor C (IL17RC)

IL17-RL; IL17R-C; IL17Rhom; Interleukin-17 receptor homolog; Interleukin-17 receptor-like protein; ZcytoR14

SPN	T431
HGNC	18358
MGI	2159336
PubMed	24060899
RGD	1306392
UniProt	Q8NAC3
Wiki	IL17RC

Interleukin-17 receptor C is a single-pass transmembrane protein that shares limited similarity with the interleukin-17 receptor. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only three have been determined to date.The predicted full-length 720-amino acid protein has an N-terminal signal peptide, followed by an acidic extracellular domain with 9 potential N-glycosylation sites, a single-pass transmembrane domain, and a basic cytoplasmic region with multiple phosphorylation sites. It has a calculated molecular mass of 76.4 kD and shares 22% amino acid identity with IL17R.strongest expression in prostate, kidney, liver, heart, and muscle, with barely detectable levels in thymus and peripheral blood leukocytes.

Reference

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer."
J. Biol. Chem. 277:4309-4316(2002) [PubMed] [Europe PMC] [Abstract]

"Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells."
Br. J. Pharmacol. 140:595-610(2003) [PubMed] [Europe PMC] [Abstract]