Interleukin 17 Receptor B (IL17RB)
IL17R-B; CRL4; EVI27; IL17BR; IL17RH1; Cytokine receptor-like 4; IL-17 receptor homolog 1
IL17RB is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.Northern blot analysis detected transcripts of 3.5 and 1.4 kb in several endocrine tissues, most pronounced in fetal and adult liver, kidney, pancreas, testis, colon, and small intestine; expression was not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines. BIAcore, flow cytometric, and Western blot analyses determined that IL17B binds with high affinity to IL17BR but only poorly to IL17R.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT430Hu01 | Recombinant Interleukin 17 Receptor B (IL17RB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT430Hu01 | Monoclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IP. |
| PAT430Hu01 | Polyclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT430Hu01 | CLIA Kit for Interleukin 17 Receptor B (IL17RB) | CLIA assay for Antigen Detection |
| ELT430Hu01 | ELISA Kit for Interleukin 17 Receptor B (IL17RB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT430Mu01 | Recombinant Interleukin 17 Receptor B (IL17RB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT430Mu01 | Monoclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IP. |
| PAT430Mu01 | Polyclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT430Mu01 | CLIA Kit for Interleukin 17 Receptor B (IL17RB) | CLIA assay for Antigen Detection |
| ELT430Mu01 | ELISA Kit for Interleukin 17 Receptor B (IL17RB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT430Ra01 | Recombinant Interleukin 17 Receptor B (IL17RB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT430Ra01 | Monoclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IP. |
| PAT430Ra01 | Polyclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT430Ra01 | CLIA Kit for Interleukin 17 Receptor B (IL17RB) | CLIA assay for Antigen Detection |
| ELT430Ra01 | ELISA Kit for Interleukin 17 Receptor B (IL17RB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT430Ca01 | Recombinant Interleukin 17 Receptor B (IL17RB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT430Ca01 | Monoclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IP. |
| PAT430Ca01 | Polyclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT430Ca01 | CLIA Kit for Interleukin 17 Receptor B (IL17RB) | CLIA assay for Antigen Detection |
| ELT430Ca01 | ELISA Kit for Interleukin 17 Receptor B (IL17RB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT430Po01 | Recombinant Interleukin 17 Receptor B (IL17RB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT430Po01 | Monoclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IP. |
| PAT430Po01 | Polyclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT430Po01 | CLIA Kit for Interleukin 17 Receptor B (IL17RB) | CLIA assay for Antigen Detection |
| ELT430Po01 | ELISA Kit for Interleukin 17 Receptor B (IL17RB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT430Bo01 | Recombinant Interleukin 17 Receptor B (IL17RB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT430Bo01 | Monoclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IP. |
| PAT430Bo01 | Polyclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT430Bo01 | CLIA Kit for Interleukin 17 Receptor B (IL17RB) | CLIA assay for Antigen Detection |
| ELT430Bo01 | ELISA Kit for Interleukin 17 Receptor B (IL17RB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT430Rb01 | Recombinant Interleukin 17 Receptor B (IL17RB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT430Rb01 | Monoclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IP. |
| PAT430Rb01 | Polyclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT430Rb01 | CLIA Kit for Interleukin 17 Receptor B (IL17RB) | CLIA assay for Antigen Detection |
| ELT430Rb01 | ELISA Kit for Interleukin 17 Receptor B (IL17RB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT430Mo01 | Recombinant Interleukin 17 Receptor B (IL17RB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT430Mo01 | Monoclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IP. |
| PAT430Mo01 | Polyclonal Antibody to Interleukin 17 Receptor B (IL17RB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT430Mo01 | CLIA Kit for Interleukin 17 Receptor B (IL17RB) | CLIA assay for Antigen Detection |
| ELT430Mo01 | ELISA Kit for Interleukin 17 Receptor B (IL17RB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Evi27 encodes a novel membrane protein with homology to the IL17 receptor."
Oncogene 19:2098-2109(2000) [PubMed] [Europe PMC] [Abstract]
"A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity."
J. Biol. Chem. 275:19167-19176(2000) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1."
J. Biol. Chem. 276:1660-1664(2001) [PubMed] [Europe PMC] [Abstract]
"An unappreciated role for RNA surveillance."
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
"Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2."
Immunobiology 217:321-328(2012) [PubMed] [Europe PMC] [Abstract]