Protein Kinase, AMP Activated Alpha 2 (PRKAa2)

AMPK; AMPK2; PRKAA; 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2; Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase

SPN	T424
HGNC	9377
MGI	1336173
PubMed	20842448
RGD	620893
UniProt	P54646
Wiki	PRKAA2

5'-AMP-activated protein kinase catalytic subunit alpha-2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Reference

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