Kruppel Like Factor 15 (KLF15)

KKLF; Kidney-Enriched Kruppel-Like Factor

SPN	T411
HGNC	14536
MGI	1929988
PubMed	22405069
RGD	70918
UniProt	Q9UIH9
Wiki	KLF15

KLF15 protein is 84% identical to the rat Klf15 protein, contains 3 zinc finger motifs at its C terminus, N-terminal serine-rich stretches, and a central proline-rich segment. EMSA analysis confirmed that KLF15 and MAZ interact with the GA element of the CLCNKA promoter and showed that KLF15 binds with higher affinity and is a functional competitor of MAZ. Northern blot analysis revealed highest expression of a 2.5-kb KLF15 transcript in liver, followed by heart, skeletal muscle, and kidney. No expression was found in bone marrow or lymphoid tissues. KLF15 was also expressed in cardiac and skeletal muscle interstitial cells and in kidney inner medulla, glomeruli, and cortical interstitium. Immunofluorescence microscopy, however, demonstrated no colocalization of KLF15 with CLCNKA.

Reference

"Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor."
Mol. Cell. Biol. 20:7319-7331(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the second C2H2-type zinc finger domain from human krueppel-like factor 15."
Submitted (APR-2008) to the PDB data bank

"Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy."
Proc. Natl. Acad. Sci. U.S.A. 104:7074-7079(2007) [PubMed] [Europe PMC] [Abstract]

Erratum
Proc. Natl. Acad. Sci. U.S.A. 104:13851-13851(2007)

"The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts."
J. Mol. Cell. Cardiol. 45:193-197(2008) [PubMed] [Europe PMC] [Abstract]

"Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity."
J. Biol. Chem. 285:27449-27456(2010) [PubMed] [Europe PMC] [Abstract]

"Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation."
Sci. Transl. Med. 2:26ra26-26ra26(2010) [PubMed] [Europe PMC] [Abstract]

"Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation."
J. Biol. Chem. 287:19122-19135(2012) [PubMed] [Europe PMC] [Abstract]

"Circadian rhythms govern cardiac repolarization and arrhythmogenesis."
Nature 483:96-99(2012) [PubMed] [Europe PMC] [Abstract]

"Kruppel-like factor 15 is critical for vascular inflammation."
J. Clin. Invest. 123:4232-4241(2013) [PubMed] [Europe PMC] [Abstract]