Glia Derived Nexin (GDN)

SERPINE2; PI7; PN1; PNI; Protease Nexin I; Serpin Peptidase Inhibitor Clade E Member 2; Peptidase inhibitor 7; Protease nexin I

SPN	T400
HGNC	8951
MGI	101780
PubMed	3371230
RGD	3748
UniProt	P07093
Wiki	SERPINE2

Protease nexin I is a 44-kD thrombin and urokinase inhibitor released by human foreskin fibroblasts. PN-I shares several features with antithrombin III , an abundant plasma thrombin inhibitor. Both PN-I and AT-III have high affinities for heparin, and heparin accelerates their rate of thrombin inhibition. In addition, the published sequence of 28 amino acids at the N-terminus of PN-I is identical to the N-terminal amino acid sequence of a glial-derived neurite promoting factor. Two forms, designated alpha and beta, were identified. These differed only by the insertion of 3 nucleotides into the coding sequence, and apparently arose by utilization of an alternative splice acceptor site in the PN1 gene. In the resulting proteins, alpha-PN-I contains an arginine residue at position 310, whereas beta-PN-I contains threonine-lysine residues.

Reference

"cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily."
Biochemistry 26:6407-6410(1987) [PubMed] [Europe PMC] [Abstract]

"A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins."
Cell 47:687-693(1986) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and expression of two forms of human protease nexin I."
Biotechnology (N.Y.) 6:172-177(1988)

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Protease nexin. Properties and a modified purification procedure."
J. Biol. Chem. 260:7029-7034(1985) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]