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Placental Thrombin Inhibitor (PTI)

SERPINB6; CAP; PI6; SPI3; Serpin Peptidase Inhibitor Clade B Member 6; Cytoplasmic antiproteinase; Peptidase inhibitor 6

PTI is a member of an emerging class of intracellular serpins.On the basis of its interaction with thrombin, through which it was discovered, the inhibitor was operationally named the placental thrombin inhibitor (PTI). Amino acid sequence comparisons suggested that its reactive center is located at arg341 and cys342, that it lacks a classic N-terminal signal sequence, and that it has the highest degree of similarity to intracellular serine proteinase inhibitors (serpins), such as the human monocyte/neutrophil elastase inhibitor (ELANH2). Analysis of human tissue mRNA indicated that PTI is expressed widely, with the highest levels in cardiac and skeletal muscle and placenta.Spi3, is developmentally regulated, and that, unlike the situation in the human, Spi3 is absent from the mouse placenta.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies MT393Hu21 Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
PT393Hu01 Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits KET393Hu ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Placental Thrombin Inhibitor (PTI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Placental Thrombin Inhibitor (PTI) Bioactivity
Antibodies NONE Monoclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Placental Thrombin Inhibitor (PTI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Placental Thrombin Inhibitor (PTI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Placental Thrombin Inhibitor (PTI) CLIA assay for Antigen Detection

Reference

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"Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases."
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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"Identification and purification of a novel serine proteinase inhibitor."
J. Biol. Chem. 268:9541-9547(1993) [PubMed] [Europe PMC] [Abstract]

"The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G."
Blood 93:2089-2097(1999) [PubMed] [Europe PMC] [Abstract]

"Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."
Blood 103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]

"SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."
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"A quantitative atlas of mitotic phosphorylation."
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"A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss."
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"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]