Proenkephalin (PENK)
Preproenkephalin; Proenkephalin-A; Synenkephalin; Met-enkephalin; Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe
- Preproenkephalin has 267 amino acids, as does proopiomelanocortin. Both genes contain 2 introns. In both, all the repeated enkephalin or melanotropin sequences are encoded by a single large exon (exon 3). Preproenkephalin mRNA encodes 4 copies of met-enkephalin, 2 copies of met-enkephalin extended sequences, and 1 copy of leu-enkephalin. Each copy is flanked by paired basic amino acids which are presumably recognized by the processing protease.
- The corresponding amino acid sequence shows that the precursor is 267 amino acids long and contains 6 interspersed Met-enkephalin sequences and 1 Leu-enkephalin sequence. The precursor does not contain the sequences of dynorphin, alpha-neo-endorphin or beta-endorphin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | T386Hu01 | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | MT386Hu21 | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| PT386Hu01 | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | KET386Hu | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | T386Mu01 | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| PT386Mu01 | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | KET386Mu | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Proenkephalin (PENK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Proenkephalin (PENK) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Proenkephalin (PENK) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Proenkephalin (PENK) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Proenkephalin (PENK) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Proenkephalin (PENK) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Proenkephalin (PENK) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Proenkephalin (PENK) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Proenkephalin (PENK) | CLIA assay for Antigen Detection |
Reference
"Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA."
Nature 295:663-666(1982) [PubMed] [Europe PMC] [Abstract]
"Isolation and structural organization of the human preproenkephalin gene."
Nature 297:431-434(1982) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The structure of synenkephalin (pro-enkephalin 1-73) is dictated by three disulfide bonds."
Biochem. Biophys. Res. Commun. 232:800-805(1997) [PubMed] [Europe PMC] [Abstract]