Myosin Heavy Chain 11, Smooth Muscle (MYH11)

AAT4; FAA4; SMHC; SMMHC; Myosin heavy chain, smooth muscle isoform

SPN	T362
HGNC	7569
MGI	102643
PubMed	11455976
RGD	3136
UniProt	P35749
Wiki	MYH11

Myosin-11 is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain.

Reference

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