Myosin Light Chain 9, Regulatory (MYL9)

MLC2; LC20; MYRL2; MRLC1; 20 kDa myosin light chain; Myosin Regulatory Light Chain 2,Smooth Muscle Isoform; Myosin Regulatory Light Chain 1

SPN	T330
HGNC	15754
MGI	1914518
PubMed	20876458
RGD	1311235
UniProt	P24844
Wiki	MYL9

MYL9is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene.

MYL9 had an apparent molecular mass of 20 kD following in vitro translation. Northern blot analysis detected a 1-kb transcript in umbilical artery, colon, and uterus, but not in cardiac or skeletal muscle. Expression was also detected in foreskin fibroblasts and human fibroblast cell lines, but not in hemopoietic cell lines. Two-dimensional gel analysis confirmed that MYL9 was present in fibroblasts, but not in T cells.

Reference

"Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells."
Biochemistry 28:4027-4035(1989) [PubMed] [Europe PMC] [Abstract]

"Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells."
Cell Struct. Funct. 26:677-683(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow."
Cell 135:123-136(2008) [PubMed] [Europe PMC] [Abstract]

"Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling."
Cell Death Differ. 18:678-689(2011) [PubMed] [Europe PMC] [Abstract]

"Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase."
FEBS Lett. 585:1260-1268(2011) [PubMed] [Europe PMC] [Abstract]

"New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform."
PLoS ONE 6:E17344-E17344(2011) [PubMed] [Europe PMC] [Abstract]