Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3)
PDHK3; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
- The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. PDK3 is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT319Hu01 | Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT319Hu01 | Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IP. |
| PAT319Hu01 | Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT319Hu01 | CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | CLIA assay for Antigen Detection |
| ELT319Hu01 | ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT319Mu01 | Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT319Mu01 | Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IP. |
| PAT319Mu01 | Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT319Mu01 | CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | CLIA assay for Antigen Detection |
| ELT319Mu01 | ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT319Ra01 | Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT319Ra01 | Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IP. |
| PAT319Ra01 | Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT319Ra01 | CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | CLIA assay for Antigen Detection |
| ELT319Ra01 | ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT319Ca01 | Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT319Ca01 | Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IP. |
| PAT319Ca01 | Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT319Ca01 | CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | CLIA assay for Antigen Detection |
| ELT319Ca01 | ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT319Po01 | Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT319Po01 | Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IP. |
| PAT319Po01 | Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT319Po01 | CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | CLIA assay for Antigen Detection |
| ELT319Po01 | ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT319Bo01 | Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT319Bo01 | Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IP. |
| PAT319Bo01 | Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT319Bo01 | CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | CLIA assay for Antigen Detection |
| ELT319Bo01 | ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT319Rb01 | Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT319Rb01 | Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IP. |
| PAT319Rb01 | Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT319Rb01 | CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | CLIA assay for Antigen Detection |
| ELT319Rb01 | ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT319Mo01 | Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT319Mo01 | Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IP. |
| PAT319Mo01 | Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT319Mo01 | CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | CLIA assay for Antigen Detection |
| ELT319Mo01 | ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Structure 15:992-1004(2007) [PubMed] [Europe PMC] [Abstract]
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Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
"A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene."
Hum. Mol. Genet. 22:1404-1416(2013) [PubMed] [Europe PMC] [Abstract]