Hypoxia Inducible Factor 2 Alpha (HIF2a)
EPAS1; HLF; MOP2; PASD2; BHLHE73; Endothelial PAS Domain 1; HIF-1 Alpha-Like Factor; Basic-helix-loop-helix-PAS protein MOP2; Class E basic helix-loop-helix protein 73
Endothelial PAS domain-containing protein 1 isa transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels.a bHLH-PAS transcription factor that induces EPO (133170) gene expression in cultured cells in response to hypoxia. Like HIF1A, EPAS1 binds to and activates transcription from the HIF1A response element derived from the 3-prime flanking region of the EPO gene. Activation by both HIF1A and EPAS1 is stimulated by hypoxic conditions. EPAS1 heterodimerizes with ARNT (126110) and requires ARNT for transcriptional activation of target genes.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT315Hu01 | Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT315Hu01 | Monoclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IP. |
| PAT315Hu01 | Polyclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT315Hu01 | CLIA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | CLIA assay for Antigen Detection |
| ELT315Hu01 | ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT315Mu01 | Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT315Mu01 | Monoclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IP. |
| PAT315Mu01 | Polyclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT315Mu01 | CLIA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | CLIA assay for Antigen Detection |
| ELT315Mu01 | ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT315Ra01 | Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT315Ra01 | Monoclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IP. |
| PAT315Ra01 | Polyclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT315Ra01 | CLIA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | CLIA assay for Antigen Detection |
| ELT315Ra01 | ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT315Ca01 | Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT315Ca01 | Monoclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IP. |
| PAT315Ca01 | Polyclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT315Ca01 | CLIA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | CLIA assay for Antigen Detection |
| ELT315Ca01 | ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT315Po01 | Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT315Po01 | Monoclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IP. |
| PAT315Po01 | Polyclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT315Po01 | CLIA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | CLIA assay for Antigen Detection |
| ELT315Po01 | ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT315Bo01 | Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT315Bo01 | Monoclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IP. |
| PAT315Bo01 | Polyclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT315Bo01 | CLIA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | CLIA assay for Antigen Detection |
| ELT315Bo01 | ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT315Rb01 | Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT315Rb01 | Monoclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IP. |
| PAT315Rb01 | Polyclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT315Rb01 | CLIA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | CLIA assay for Antigen Detection |
| ELT315Rb01 | ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT315Mo01 | Recombinant Hypoxia Inducible Factor 2 Alpha (HIF2a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT315Mo01 | Monoclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IP. |
| PAT315Mo01 | Polyclonal Antibody to Hypoxia Inducible Factor 2 Alpha (HIF2a) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT315Mo01 | CLIA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | CLIA assay for Antigen Detection |
| ELT315Mo01 | ELISA Kit for Hypoxia Inducible Factor 2 Alpha (HIF2a) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells."
Genes Dev. 11:72-82(1997) [PubMed] [Europe PMC] [Abstract]
"Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway."
J. Biol. Chem. 272:8581-8593(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300."
EMBO J. 18:1905-1914(1999) [PubMed] [Europe PMC] [Abstract]
"Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline."
J. Biol. Chem. 284:9050-9058(2009) [PubMed] [Europe PMC] [Abstract]
"Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis."
Blood 111:5400-5402(2008) [PubMed] [Europe PMC] [Abstract]
"A gain-of-function mutation in the HIF2A gene in familial erythrocytosis."
N. Engl. J. Med. 358:162-168(2008) [PubMed] [Europe PMC] [Abstract]
"Two new mutations in the HIF2A gene associated with erythrocytosis."
Am. J. Hematol. 87:439-442(2012) [PubMed] [Europe PMC] [Abstract]