Pappalysin 2 (PAPPA2)

PAPP-A2; PAPPE; PLAC3; Placenta-Specific 3; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1

SPN	T310
HGNC	14615
MGI	3051647
PubMed	21496272
UniProt	Q9BXP8
Wiki	PAPPA2

Pappalysins comprise one of the five families of Metzincins (other families include ADAMs/ADAMTSs, MMPs, Astacins, and Serralysins). Pappalysin-1 (PAPP-A) is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy. Reduced maternal serum PAPP-A is a major marker of Down syndrome in the first trimester of pregnancy. PAPP-A cleaves IGFBP-4 and -5 (insulin-like growth factor-binding protein-4 and 5) at a single site, resulting in the release of bioactive IGF.

Pappalysin-2 (PAPP-A2; also called PAPP-E) shares 45% amino acid identity with PAPP-A and cleaves IGFBP-2.sialic acid binding Ig-like lectin 6 (Siglec-6), a potential leptin receptor, and pappalysin-2 (PAPP-A2), a protease that cleaves IGF-binding proteins

Reference

"Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase."
J. Biol. Chem. 276:21849-21853(2001) [PubMed] [Europe PMC] [Abstract]

"The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant."
Placenta 22:681-687(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Pregnancy-associated plasma protein-E (PAPP-E)."
Biochim. Biophys. Acta 1493:356-362(2000) [PubMed] [Europe PMC] [Abstract]