5-Hydroxytryptamine Receptor 2C (HTR2C)

5-HT2C; HTR1C; Serotonin Receptor 2C; 5-hydroxytryptamine receptor 1C

SPN	T293
HGNC	5295
MGI	96281
PubMed	19142101
RGD	2848
UniProt	P28335
Wiki	HTR2C

HTR2Cencodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.The 5-HT_2C receptor is one of the many binding sites for serotonin. Activation of this receptor by serotonin inhibits dopamine and norepinephrine release in certain areas of the brain.

Reference

"Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes."
Biochem. Biophys. Res. Commun. 181:1469-1478(1991) [PubMed] [Europe PMC] [Abstract]

"Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor."
Eur. J. Pharmacol. 269:339-348(1994) [PubMed] [Europe PMC] [Abstract]

"The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant."
Genomics 35:551-561(1996) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of RNA editing events within the 5-HT2C receptor."
Ann. N. Y. Acad. Sci. 861:38-48(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1."
J. Biol. Chem. 276:12974-12982(2001) [PubMed] [Europe PMC] [Abstract]

"Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy."
Br. J. Pharmacol. 140:277-284(2003) [PubMed] [Europe PMC] [Abstract]

"A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors."
J. Biol. Chem. 281:2932-2938(2006) [PubMed] [Europe PMC] [Abstract]

"Serotonin receptors."
Chem. Rev. 108:1614-1641(2008) [PubMed] [Europe PMC] [Abstract]

"Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells."
Eur. J. Pharmacol. 594:32-38(2008) [PubMed] [Europe PMC] [Abstract]

"Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors."
Naunyn Schmiedebergs Arch. Pharmacol. 379:461-471(2009) [PubMed] [Europe PMC] [Abstract]

"Serotonin receptors - from molecular biology to clinical applications."
Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]

"The N-terminal region of the human 5-HT(2)C receptor has as a cleavable signal peptide."
Eur. J. Pharmacol. 684:44-50(2012) [PubMed] [Europe PMC] [Abstract]

"Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C)."
Genomics 27:274-279(1995) [PubMed] [Europe PMC] [Abstract]

"Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability."
Am. J. Med. Genet. 88:126-130(1999) [PubMed] [Europe PMC] [Abstract]

"Unified approach to the analysis of genetic variation in serotonergic pathways."
Am. J. Med. Genet. 88:621-627(1999) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)