Heat Shock Protein Beta 3 (HSPb3)

HSP-B3; HSPL27; HSP27; HSP 17; Heat Shock 27kDa Protein 3; Heat shock 17 kDa protein

SPN	T277
HGNC	5248
MGI	1928479
PubMed	22610661
RGD	68345
UniProt	Q12988
Wiki	HSPB3

Small heat-shock proteins are characterized by a conserved sequence of 80 to 100 amino acids, often called the alpha-crystallin domain, and range in size from 12 to 43 kD in the monomeric state; as multimeric complexes, they range from 150 to 800 kD.

By partial sequencing of cDNA clones and sequence database searching, Lam et al. (1996) isolated an adult heart cDNA that encodes a novel small heat-shock protein of 241 amino acids. Because of its high sequence homology with hsp27, they termed the protein heat-shock protein 27-like protein (HSPL27). It contains casein kinase II but not MAP kinase recognition sites. Northern blot analysis revealed expression of a 0.9-kb transcript in smooth muscle only.

Reference

"HspB3, the most deviating of the six known human small heat shock proteins."
Biochim. Biophys. Acta 1388:513-516(1998) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of a human heart cDNA encoding a new member of the small heat shock protein family -- HSPL27."
Biochim. Biophys. Acta 1314:120-124(1996) [PubMed] [Europe PMC] [Abstract]

"HSPB7 is a SC35 speckle resident small heat shock protein."
Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]

"Mutant small heat shock protein B3 causes motor neuropathy: utility of a candidate gene approach."
Neurology 74:502-506(2010) [PubMed] [Europe PMC] [Abstract]