Corticotropin Releasing Hormone Receptor 2 (CRHR2)
CRFR2; CRF2; Corticotropin-releasing factor receptor 2
Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide synthesized in the hypothalamus. It is the principal neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Liaw et al. (1996) stated that there are 2 G protein-coupled CRH receptors, CRHR1 and CRHR2, which they termed the CRF2 receptor. The investigators used clones of the rat CRF2 receptor to isolate the human gene from brain and kidney genomic DNA libraries. The gene consists of 12 exons spanning approximately 30 kb. The predicted protein, which is 411 amino acids in length and 70% identical to the CRF1 receptor, contains a putative N-terminal secretory signal sequence and 7 putative transmembrane domains.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT270Hu01 | Recombinant Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT270Hu01 | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IP. |
| PAT270Hu01 | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT270Hu01 | CLIA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | CLIA assay for Antigen Detection |
| ELT270Hu01 | ELISA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT270Mu01 | Recombinant Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT270Mu01 | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IP. |
| PAT270Mu01 | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT270Mu01 | CLIA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | CLIA assay for Antigen Detection |
| ELT270Mu01 | ELISA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT270Ra01 | Recombinant Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT270Ra01 | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IP. |
| PAT270Ra01 | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT270Ra01 | CLIA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | CLIA assay for Antigen Detection |
| ELT270Ra01 | ELISA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT270Ca01 | Recombinant Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT270Ca01 | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IP. |
| PAT270Ca01 | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT270Ca01 | CLIA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | CLIA assay for Antigen Detection |
| ELT270Ca01 | ELISA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT270Po01 | Recombinant Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT270Po01 | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IP. |
| PAT270Po01 | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT270Po01 | CLIA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | CLIA assay for Antigen Detection |
| ELT270Po01 | ELISA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT270Bo01 | Recombinant Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT270Bo01 | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IP. |
| PAT270Bo01 | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT270Bo01 | CLIA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | CLIA assay for Antigen Detection |
| ELT270Bo01 | ELISA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT270Rb01 | Recombinant Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT270Rb01 | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IP. |
| PAT270Rb01 | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT270Rb01 | CLIA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | CLIA assay for Antigen Detection |
| ELT270Rb01 | ELISA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT270Mo01 | Recombinant Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT270Mo01 | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IP. |
| PAT270Mo01 | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 2 (CRHR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT270Mo01 | CLIA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | CLIA assay for Antigen Detection |
| ELT270Mo01 | ELISA Kit for Corticotropin Releasing Hormone Receptor 2 (CRHR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid."
Endocrinology 137:72-77(1996) [PubMed] [Europe PMC] [Abstract]
"Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor."
Mol. Endocrinol. 12:1077-1085(1998) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor."
Biochim. Biophys. Acta 1352:129-132(1997) [PubMed] [Europe PMC] [Abstract]
"The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization."
J. Biol. Chem. 287:27265-27274(2012) [PubMed] [Europe PMC] [Abstract]
"Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]