Mitogen Activated Protein Kinase 9 (MAPK9)

JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; PRKM9; p54a; SAPK; Jun Kinase; Stress-activated protein kinase 1a; c-Jun N-terminal kinase 2

SPN	T208
HGNC	6886
MGI	1346862
PubMed	21110917
RGD	628847
UniProt	P45984
Wiki	MAPK9

Mitogen-activated protein kinase 9 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells.

Reference

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Mol. Cell. Biol. 14:8376-8384(1994) [PubMed] [Europe PMC] [Abstract]

"JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation."
Genes Dev. 8:2996-3007(1994) [PubMed] [Europe PMC] [Abstract]

"Selective interaction of JNK protein kinase isoforms with transcription factors."
EMBO J. 15:2760-2770(1996) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of novel human JNK2 (MAPK9) transcript variants that show different stimulation activities on AP-1."
BMB Rep. 43:738-743(2010) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Role of the ATFa/JNK2 complex in Jun activation."
Oncogene 18:3491-3500(1999) [PubMed] [Europe PMC] [Abstract]

"Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7."
Biochem. J. 352:145-154(2000) [PubMed] [Europe PMC] [Abstract]

"Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein."
Biochem. J. 389:73-82(2005) [PubMed] [Europe PMC] [Abstract]

"The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis."
Genes Dev. 19:933-941(2005) [PubMed] [Europe PMC] [Abstract]

"Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation."
Cancer Res. 67:8725-8735(2007) [PubMed] [Europe PMC] [Abstract]

"The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway."
Immunity 26:55-66(2007) [PubMed] [Europe PMC] [Abstract]

"Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway."
Oncogene 26:7222-7230(2007) [PubMed] [Europe PMC] [Abstract]

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Immunol. Rev. 228:199-211(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"GSK3beta is involved in JNK2-mediated beta-catenin inhibition."
PLoS ONE 4:E6640-E6640(2009) [PubMed] [Europe PMC] [Abstract]

"c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium."
Am. J. Physiol. 299:G572-G584(2010) [PubMed] [Europe PMC] [Abstract]

"JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis."
Cell Death Dis. 1:E29-E29(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"JNK regulates the photic response of the mammalian circadian clock."
EMBO Rep. 13:455-461(2012) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity."
J. Mol. Biol. 383:885-893(2008) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]