Mitogen Activated Protein Kinase 12 (MAPK12)

ERK6; PRKM12; p38 Gamma; SAPK3; Stress-activated protein kinase 3; Extracellular signal-regulated kinase 6; Mitogen-activated protein kinase p38 gamma

SPN	T207
HGNC	6874
MGI	1353438
PubMed	8920915
RGD	70975
UniProt	P53778
Wiki	MAPK12

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.By screening with sequences based on those of the rat ERK3 gene, Lechner et al. (1996) isolated an ERK6 clone from a human skeletal muscle cDNA library. They reported that ERK6 appears to function as a signal transducer during differentiation of myoblasts to myotubes. Li et al. (1996) stated that SAPK3 is probably identical to the ERK6 gene cloned by Lechner et al. (1996).

Reference

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Proc. Natl. Acad. Sci. U.S.A. 93:4355-4359(1996) [PubMed] [Europe PMC] [Abstract]

"Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization."
Genomics 41:501-502(1997) [PubMed] [Europe PMC] [Abstract]

"The primary structure of p38 gamma: a new member of p38 group of MAP kinases."
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."
J. Biol. Chem. 273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]

"Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition."
J. Biol. Chem. 274:12626-12631(1999) [PubMed] [Europe PMC] [Abstract]

"Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength."
J. Biol. Chem. 275:40641-40648(2000) [PubMed] [Europe PMC] [Abstract]

"Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest."
Mol. Cell. Biol. 20:4543-4552(2000) [PubMed] [Europe PMC] [Abstract]

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Biochem. J. 367:577-585(2002) [PubMed] [Europe PMC] [Abstract]

"p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle."
Am. J. Physiol. 286:R342-R349(2004) [PubMed] [Europe PMC] [Abstract]

"Active mutants of the human p38alpha mitogen-activated protein kinase."
J. Biol. Chem. 279:47040-47049(2004) [PubMed] [Europe PMC] [Abstract]

"p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response."
J. Biol. Chem. 282:31398-31408(2007) [PubMed] [Europe PMC] [Abstract]

"p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock."
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"Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death."
J. Cell Sci. 124:216-227(2011) [PubMed] [Europe PMC] [Abstract]

"p38gamma mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer."
Neoplasia 13:472-482(2011) [PubMed] [Europe PMC] [Abstract]

"Mechanisms and functions of p38 MAPK signalling."
Biochem. J. 429:403-417(2010) [PubMed] [Europe PMC] [Abstract]

"The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation."
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"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]