Phosphoenolpyruvate Carboxykinase 2, Mitochondrial (PCK2)

PEPCK; PEPCK2

SPN	T201
HGNC	8725
MGI	1860456
PubMed	24632615
RGD	1311112
UniProt	Q16822

Phosphoenolpyruvate Carboxykinase 2,Mitochondrial is a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver.

The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. PCK2 activation mediates an adaptive response to glucose depletion in lung cancer.

Reference

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