Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11)

BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2; Noonan Syndrome 1; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C

SPN	T200
HGNC	9644
MGI	99511
PubMed	11704759
RGD	3447
UniProt	Q06124
Wiki	PTPN11

PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates.

This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Reference

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Erratum
Nat. Genet. 29:491-491(2001)

Erratum
Nat. Genet. 30:123-123(2001)

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Erratum
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