Protein Tyrosine Phosphatase, Non Receptor Type 22 (PTPN22)

LYP; PEP; Lyp1; Lyp2; PTPN8; Lymphoid phosphatase; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; PEST-domain phosphatase

SPN	T187
HGNC	9652
MGI	107170
PubMed	15934099
RGD	1307992
UniProt	Q9Y2R2
Wiki	PTPN22

Protein tyrosine phosphatase, non-receptor type 22 (lymphoid) is located on the short arm of Chromosome 1 near the telomere (1p13.2) on the Crick (minus) strand. It is 57,898 bases in length and encodes a protein of 807 amino acids (molecular weight 91,705 Da). There are 24 exons in the gene and 21 transcript variants encoding 10 distinct proteins are known. The proteins are located in the cytoplasm.

This gene encodes a protein tyrosine phosphatase which is expressed primarily in lymphoid tissues. This enzyme associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T cell receptor signaling pathway.

Reference

"Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp."
Blood 93:2013-2024(1999) [PubMed] [Europe PMC] [Abstract]

"Identification of a variant form of tyrosine phosphatase LYP."
BMC Mol. Biol. 11:78-78(2010) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of substrates of human protein-tyrosine phosphatase PTPN22."
J. Biol. Chem. 281:11002-11010(2006) [PubMed] [Europe PMC] [Abstract]

"Protein tyrosine phosphatase PTPN22 in human autoimmunity."
Autoimmunity 40:453-461(2007) [PubMed] [Europe PMC] [Abstract]

"PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis."
PLoS ONE 7:E33067-E33067(2012) [PubMed] [Europe PMC] [Abstract]

"The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity."
Immunity 39:111-122(2013) [PubMed] [Europe PMC] [Abstract]

"Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy."
PLoS ONE 8:E72384-E72384(2013) [PubMed] [Europe PMC] [Abstract]

"Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases."
Proc. Natl. Acad. Sci. U.S.A. 104:19767-19772(2007) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation."
Biochemistry 48:4838-4845(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale structural analysis of the classical human protein tyrosine phosphatome."
Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]

"A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus."
Hum. Mol. Genet. 18:569-579(2009) [PubMed] [Europe PMC] [Abstract]

"Lyp/PTPN22 phosphatase domain: substrate recognition and specificity for Src family kinases."
Submitted (DEC-2009) to the PDB data bank

"Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate."
J. Biol. Chem. 286:30526-30534(2011) [PubMed] [Europe PMC] [Abstract]

"A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis."
Am. J. Hum. Genet. 75:330-337(2004) [PubMed] [Europe PMC] [Abstract]

"Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE."
Am. J. Hum. Genet. 75:504-507(2004) [PubMed] [Europe PMC] [Abstract]

"A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes."
Nat. Genet. 36:337-338(2004) [PubMed] [Europe PMC] [Abstract]

"The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease."
J. Clin. Endocrinol. Metab. 89:5862-5865(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes."
Am. J. Hum. Genet. 76:561-571(2005) [PubMed] [Europe PMC] [Abstract]

"A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo."
Genes Immun. 6:584-587(2005) [PubMed] [Europe PMC] [Abstract]

"Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling."
J. Immunol. 182:3343-3347(2009) [PubMed] [Europe PMC] [Abstract]

"Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis."
Inflamm. Bowel Dis. 17:2287-2294(2011) [PubMed] [Europe PMC] [Abstract]

"Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W."
PLoS ONE 7:E43631-E43631(2012) [PubMed] [Europe PMC] [Abstract]