Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ)

PTPRZ1; HPTPZ; HPTPzeta; PTP18; PTPR-Z; PTPZ; RPTPB; RPTPbeta; Phosphacan; Receptor-type tyrosine-protein phosphatase zeta

SPN	T177
HGNC	9685
MGI	97816
PubMed	20133774
RGD	3455
UniProt	P23471

Receptor-type tyrosine-protein phosphatase zeta is a member of the receptor type protein tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type-III domain.

Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.

Reference

"A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases."
Proc. Natl. Acad. Sci. U.S.A. 89:7417-7421(1992) [PubMed] [Europe PMC] [Abstract]

"The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system."
J. Biol. Chem. 268:10573-10581(1993) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and expression analysis of five novel genes in chromosome 1p36."
Genomics 50:187-198(1998) [PubMed] [Europe PMC] [Abstract]

"Structural diversity and evolution of human receptor-like protein tyrosine phosphatases."
EMBO J. 9:3241-3252(1990) [PubMed] [Europe PMC] [Abstract]

"Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain."
Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1990) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]