Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2)

IA-2beta; IAR; ICAAR; PTPRP; PTPR-N2; Phogrin; Islet cell autoantigen-related protein

SPN	T173
HGNC	9677
MGI	107418
PubMed	9858807
RGD	61904
UniProt	Q92932
Wiki	PTPRN2

Receptor-type tyrosine-protein phosphatase N2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Reference

"Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes."
Biochem. Biophys. Res. Commun. 227:440-447(1996) [PubMed] [Europe PMC] [Abstract]

"ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins."
Biochem. Biophys. Res. Commun. 229:402-411(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes."
J. Biol. Chem. 271:24817-24823(1996) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale structural analysis of the classical human protein tyrosine phosphatome."
Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]