Protein Tyrosine Phosphatase Like Protein A (PTPLA)
CAP; HACD1; Proline Instead Of Catalytic Arginine Member a; 3-hydroxyacyl-CoA dehydratase 1; Cementum Attachment Protein; Very-long-chain 3R-3-hydroxyacyl-CoA dehydratase 1
PTPLA contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. Highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT172Hu01 | Recombinant Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT172Hu01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IP. |
| PAT172Hu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT172Hu01 | CLIA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | CLIA assay for Antigen Detection |
| ELT172Hu01 | ELISA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT172Mu01 | Recombinant Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT172Mu01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IP. |
| PAT172Mu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT172Mu01 | CLIA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | CLIA assay for Antigen Detection |
| ELT172Mu01 | ELISA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT172Ra01 | Recombinant Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT172Ra01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IP. |
| PAT172Ra01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT172Ra01 | CLIA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | CLIA assay for Antigen Detection |
| ELT172Ra01 | ELISA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT172Ca01 | Recombinant Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT172Ca01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IP. |
| PAT172Ca01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT172Ca01 | CLIA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | CLIA assay for Antigen Detection |
| ELT172Ca01 | ELISA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT172Po01 | Recombinant Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT172Po01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IP. |
| PAT172Po01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT172Po01 | CLIA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | CLIA assay for Antigen Detection |
| ELT172Po01 | ELISA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT172Bo01 | Recombinant Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT172Bo01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IP. |
| PAT172Bo01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT172Bo01 | CLIA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | CLIA assay for Antigen Detection |
| ELT172Bo01 | ELISA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT172Rb01 | Recombinant Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT172Rb01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IP. |
| PAT172Rb01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT172Rb01 | CLIA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | CLIA assay for Antigen Detection |
| ELT172Rb01 | ELISA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT172Mo01 | Recombinant Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT172Mo01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IP. |
| PAT172Mo01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Like Protein A (PTPLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT172Mo01 | CLIA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | CLIA assay for Antigen Detection |
| ELT172Mo01 | ELISA Kit for Protein Tyrosine Phosphatase Like Protein A (PTPLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human protein tyrosine phosphatase-like gene: expression profile, genomic structure, and mutation analysis in families with ARVD."
Gene 256:237-243(2000) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene."
Genomics 62:406-416(1999) [PubMed] [Europe PMC] [Abstract]
"Isolation of protein-tyrosine phosphatase-like member-a variant from cementum."
J. Dent. Res. 91:203-209(2012) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis."
FEBS Lett. 582:2435-2440(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Congenital myopathy is caused by mutation of HACD1."
Hum. Mol. Genet. 22:5229-5236(2013) [PubMed] [Europe PMC] [Abstract]
"Human recombinant cementum attachment protein (hrPTPLa/CAP) promotes hydroxyapatite crystal formation in vitro and bone healing in vivo."
Bone 69:154-164(2014) [PubMed] [Europe PMC] [Abstract]