Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3)
PRL3; PRL-3; PRL-R; Protein-tyrosine phosphatase of regenerating liver 3; Protein-tyrosine phosphatase 4a3
Protein tyrosine phosphatase type IVA 3 is an enzyme belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT169Hu01 | Recombinant Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT169Hu01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IP. |
| PAT169Hu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT169Hu01 | CLIA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | CLIA assay for Antigen Detection |
| ELT169Hu01 | ELISA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT169Mu01 | Recombinant Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT169Mu01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IP. |
| PAT169Mu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT169Mu01 | CLIA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | CLIA assay for Antigen Detection |
| ELT169Mu01 | ELISA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT169Ra01 | Recombinant Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT169Ra01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IP. |
| PAT169Ra01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT169Ra01 | CLIA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | CLIA assay for Antigen Detection |
| ELT169Ra01 | ELISA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT169Ca01 | Recombinant Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT169Ca01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IP. |
| PAT169Ca01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT169Ca01 | CLIA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | CLIA assay for Antigen Detection |
| ELT169Ca01 | ELISA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT169Po01 | Recombinant Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT169Po01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IP. |
| PAT169Po01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT169Po01 | CLIA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | CLIA assay for Antigen Detection |
| ELT169Po01 | ELISA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT169Bo01 | Recombinant Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT169Bo01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IP. |
| PAT169Bo01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT169Bo01 | CLIA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | CLIA assay for Antigen Detection |
| ELT169Bo01 | ELISA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT169Rb01 | Recombinant Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT169Rb01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IP. |
| PAT169Rb01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT169Rb01 | CLIA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | CLIA assay for Antigen Detection |
| ELT169Rb01 | ELISA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT169Mo01 | Recombinant Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT169Mo01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IP. |
| PAT169Mo01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT169Mo01 | CLIA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | CLIA assay for Antigen Detection |
| ELT169Mo01 | ELISA Kit for Protein Tyrosine Phosphatase Type IVA 3 (PTP4A3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38."
Recept. Signal Transduct. 7:241-256(1997) [PubMed] [Europe PMC] [Abstract]
"Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling."
Biochem. Biophys. Res. Commun. 283:1061-1068(2001) [PubMed] [Europe PMC] [Abstract]
"A phosphatase associated with metastasis of colorectal cancer."
Science 294:1343-1346(2001) [PubMed] [Europe PMC] [Abstract]
"The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis."
J. Biol. Chem. 277:46659-46668(2002) [PubMed] [Europe PMC] [Abstract]
"Pentamidine is an inhibitor of PRL phosphatases with anticancer activity."
Mol. Cancer Ther. 1:1255-1264(2002) [PubMed] [Europe PMC] [Abstract]
"PRL-3 and PRL-1 promote cell migration, invasion, and metastasis."
Cancer Res. 63:2716-2722(2003) [PubMed] [Europe PMC] [Abstract]
"Structure of human PRL-3, the phosphatase associated with cancer metastasis."
FEBS Lett. 565:181-187(2004) [PubMed] [Europe PMC] [Abstract]
"Structural insights into molecular function of the metastasis-associated phosphatase PRL-3."
J. Biol. Chem. 279:11882-11889(2004) [PubMed] [Europe PMC] [Abstract]