ATP Binding Cassette Transporter E1 (ABCE1)

ABC-E1; RLI; OABP; RNASEL1; RNASELI; RNS4I; HuHP68; 2'-5'-oligoadenylate-binding protein; RNase L inhibitor; Ribonuclease 4 inhibitor

SPN	T163
HGNC	69
MGI	1195458
PubMed	17233757
RGD	1305301
UniProt	P61221
Wiki	ABCE1

RLI is a 68 kDa cytoplasmic protein found in most eukaryota and archae. Since the crystal structure for RLI has not yet been determined, all that is known has been inferred from protein sequencing. The protein sequences between species is very well conserved, for example Pixie and yeast Rli1p are 66% identical, and Rli1p and human RLI are 67% identical. RLI belongs to the ABCE family of ATP-binding cassette (ABC) proteins. ABC proteins typically also contain a transmembrane region, and utilize ATP to transport substrates across a membrane, however RLI is unique in that it is a soluble protein that contains ABC domains. RLI has two C-terminal ABC domains; upon binding ATP they form a characteristic “ATP-sandwich,” with two ATP molecules sandwiched between the two dimerized ABC domains.

Reference

"Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2-5A pathway."
J. Biol. Chem. 270:13308-13317(1995) [PubMed] [Europe PMC] [Abstract]

"Chromosomal localization and expression pattern of the RNase L inhibitor gene."
FEBS Lett. 381:135-139(1996) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells."
Eur. J. Biochem. 254:248-255(1998) [PubMed] [Europe PMC] [Abstract]

"RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells."
J. Virol. 73:290-296(1999) [PubMed] [Europe PMC] [Abstract]

"The 2-5A/RNase L/RNase L inhibitor (RNI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells."
J. Biol. Chem. 276:48473-48482(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of a host protein essential for assembly of immature HIV-1 capsids."
Nature 415:88-92(2002) [PubMed] [Europe PMC] [Abstract]

"Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells."
J. Virol. 78:1645-1656(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data."
J. Proteome Res. 6:2331-2340(2007) [PubMed] [Europe PMC] [Abstract]